Atlanta hosts a Week 1 shootout-ready stage for Penix Jr. as he pairs with Bijan Robinson and Drake London to form a potent fantasy trio. Tristan Wirfs’ knee injury could tilt pass-protection in Tampa Bay’s favor, amplifying Atlanta’s healthy edge via Pearce Jr. and Walker on the edge. Seattle's ground tempo vs. San Francisco hinges on Grey Zabel’s elite preseason run-blocking, signaling a more balanced attack. Week 1 underdog angles point to value bets and start/sit intrigue for Penix, Robinson and London in shallow rosters.

Parsons to Green Bay reshapes the NFC power structure, elevating the Packers while the Rams grapple with Stafford’s back issue. Love’s development and SF’s weaponry keep the conference competitive, with Detroit, Tampa Bay, and Atlanta lurking for playoff spots as the season opens.

Ricky Pearsall is under real pressure to be the 49ers’ Week 1 spark in 2025. With Brandon Aiyuk likely out four to six games and Jauan Jennings dealing with a calf issue, Pearsall faces a featured role early, surrounded by Russell Gage and Marquez Valdes-Scantling. A productive start could unlock SF’s ceiling; a slow one could derail the early schedule against Seattle and New Orleans. The offense’s success hinges on Pearsall’s progression and how quickly the other top receivers return to form.

His 1.31 yards per route run screams inefficiency, but the late-season surge showed what he can do when given targets. If he builds on that momentum and translates it to a more demanding role against sharper cornerbacks, the 49ers could turn a potentially rough start into “best offense in the NFL” momentum as Aiyuk, Jennings, and Robinson rejoin the lineup.

Jennings’ Week 1 status is uncertain as calf issues linger, with Lynch saying progress but no clear timeline for a return. San Francisco’s WR room is thin to start the season, especially with Brandon Aiyuk on the PUP list. The 49ers shuffled depth by adding Marquez Valdes-Scantling and trading for Skyy Moore, while Jennings’ ongoing contract pursuit adds a layer of drama to the fantasy picture.

Sea­son-opening questions center on how SF distributes targets behind Kittle and in a run-first attack. Robinson and Moore join the mix as Week 1 low-cost, high-upside options if Jennings is limited or out. The juxtaposition of contract chatter and calf rehab shapes a volatile but potentially fruitful fantasy floor for SF’s pass game.